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Discover new possibilities to enhance purification and formulation of


Download the free DAVISIL® Chromatographic Silica Purification of Omega-3 Fatty Acids from Fish Oil Technical Data Sheet

Regulatory requirements in the nutraceutical space are growing increasingly stringent. Grace’s 50-year tenure in the space has enabled our team to commercialize high-performance resins and excipients for preparative and process scale separation for Omega-3s. Grace resins and excipients improve purity and create better targeted and higher value formulations with enhanced bioavailability.

Discover how Grace is solving purification and formulation issues in Omega-3s

  • High quality separation capabilities: Highly defined pore structures: internal porosities that deliver outstanding adsorption, narrow particle size distribution and increased internal surface area for functionality
  • Customization: Grace offers the widest range of pore diameters, particle sizes, and chromatography phases and engineering capabilities that allow particle properties to be fine-tuned to meet your specific needs
  • Reliability and Speed to Market: Our batch-to-batch consistency and reproducibility drive agility for our customers supporting faster commercialization
  • Compliance: Made according to Good Manufacturing Practice (cGMP) guidelines, with EXCiPACT® certification. Most Grace silicas are also patented and listed on the FDA inactive ingredient database.


Our brands and features in Purification and Formulation include:


Grace DAVISIL® Chromatography silica products remove waxes, pigments, heavy metals, PAHs, PCBs, and pesticides.



DAVISIL® LC 150Å silica

Used in the pre-treatment of fish oil, removing soaps, phospholipids, and other impurities.

DAVISIL® LC 60Å silica

Effective in removal of pigments and degradation products that result in an undesirable color profile.

DAVISIL® LC 30Å silica

Used to eliminate pesticides, polyaromatic hydrocarbons, polychlorinated biphenyls, and heavy metals.

DAVISIL® Xtract Amino HP silica

Amino-bonded DAVISIL® silica facilitates the production of high potency EPA/DHA Omega-3 fatty acids by:

  • Optimized carbon loading, which offers superior resin stability and lifetime
  • High surface area, low impurity content and high carbon load provide improved resolution factor and yield

DAVISIL® Xtract C18 silica

C18-bonded DAVISIL® silica facilitates the separation of EPA and DHA by:

  • Low pressure drop, high efficiency separations ideal for process scale chromatography separations
  • High surface area and carbon load result in improved resolution factor and yield



Grace SYLOID® solutions create stability, flow, or bioavailability.



SYLOID® XDP silica

Solid carrier that has been specifically designed for converting lipids including Omega-3 fatty acids into free-flowing powders. They are excellent adsorbents for Self-Emulsifying Nutraceutical Systems.

SYLOID® 244F silica Multifunctional excipient with uniquely designed mesoporous structure and large internal surface area used to provide moisture protection, preserve flavor, and improve flow.
SYLOID® G 156FP silica Specially designed micronized, dense silica to improve the flow of Omega-3 powders; this high density cost-effective glidant offers several manufacturing and cost-in-use benefits.


About Grace

W. R. Grace & Co. is a leading global innovator built on talent, technology and trust. We serve customers in 60 countries and have over 4,000 highly skilled employees worldwide. Our teams are dedicated to helping you get your product to market through advanced technology, innovative science, and the strictest oversight.

Our extensive experience with the stringent regulatory and quality requirements in the pharmaceutical industry, technical capabilities, customer service, global presence, and culture of continuous innovation round out a partnership you can trust in today’s dynamic global pharmaceutical and biotech industry.