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SYLOID® 244 FP Silica: A multi-purpose excipient

SYLOID® 244 FP silica acts as a glidant, offers moisture protection and anti-tacking properties, and can be used as a suspension aid in tablet coatings.

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SYLOID® FP silica’s unique, innovative design combines adsorption capacity, particle size, density, and internal surface area to provide multifunctional benefits or optimize an application. This helps minimize the number of excipients used and the complexity of formulations while expediting manufacturing, ultimately improving the efficacy of the final dosage form.

 

Grace’s SYLOID® 244 FP silica act as free-flow and anti-caking agents and serve the following functions: 

  • Can create unique interactions, charges, and capillary forces resulting in improved powder-flow, glidants, and anti-caking behaviors due to the controlled porous morphology
  • Form a micro-structured surface on sticky particles to prevent agglomeration
  • Adsorb a considerable amount of moisture, keeping the product dry and improving the stability due to the high porosity
  • Adsorb excess moisture from the atmosphere before it can be absorbed by the bulk powder
  • Adsorb moisture and oil diffusing out of the bulk powder

Grace’s silicas are of high purity, chemically inert, and are very efficient in helping to ensure free-flow, even for the most troublesome powdered supplement products. 

EP monograph Silica, colloidal hydrated and USP monograph Silicon Dioxide compliant

 

Benefits of SYLOID® FP Silica Excipients for Moisture Control and Adsorption

  • Improved product uniformity during blending
  • Increased efficiency
    • Low usage levels, lower cost
    • High carrying level
  • Protection against moisture pick up
  • Reduced dusting during production
  • Decreased tablet weight variation
  • Lower friability and improved tablet hardness
  • Increased production rates
  • Allows direct compression instead of granulation processes 

 

SYLOID® mesoporous silicas have been reliable solutions for pharmaceutical and nutraceutical formulations for decades, offering:

 

Highly defined pore structures – internal porosities that deliver outstanding adsorption, equal particle size distribution and increased internal surface area for functionality Greater density particles – reduced dust and more compact storage Customization – pore volume, diameter, size distribution and internal surface area Made according to Good Manufacturing Practices (cGMP) guidelines, with EXCiPACT® certification. SYLOID® silicas are also patented and listed on the FDA inactive ingredient database

 

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